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عمومی::
زمان پرترومبین، زمان پرترومبین، آزمایش زمان پروترومبین
More than 30 years ago, a landmark article examining the relationship between cirrhosis, abdominal surgery, and outcomes demon- strated mortality rates approaching 80% in patients with cirrhosis and a prothrombin time more than 2.5 seconds longer than in control subjects who underwent cholecystectomy. ftese fatalities were attributable to intra-abdominal hemorrhage, progressive hepatic and renal failure, and upper gastrointestinal hemorrhage resulting from portal hypertension.
Prothrombin time was identi- fied as a better marker of hepatocellular function than albumin because prothrombin more accurately estimates biosynthetic function of the liver.
More recently, the Model for End-Stage Liver Disease score has been used to guide patient selection and prog- nosticate morbidity and mortality in patients with chronic liver disease undergoing major operations. fte score is determined through calculations incorporating serum bilirubin, prothrombin time/international normalized ratio, and creatinine and has been predictive in several studies looking at outcomes. fte Model for End-Stage Liver Disease has largely supplanted older subjective predictive models of outcomes such as Child-Pugh.
thromboplastin time, and the extrinsic pathway, initiated by tissue injury and release of tissue factor, is measured by the prothrombin time.
Prothrombin time and partial thromboplastin time are not functional tests of clotting and are limited in assessing clot strength, durability, or the quality of the clot formed by the inter- play of platelets, von Willebrand factor, and fibrin.،More than 30 years ago, a landmark article examining the relationship between cirrhosis, abdominal surgery, and outcomes demon- strated mortality rates approaching 80% in patients with cirrhosis and a prothrombin time more than 2.5 seconds longer than in control subjects who underwent cholecystectomy. ftese fatalities were attributable to intra-abdominal hemorrhage, progressive hepatic and renal failure, and upper gastrointestinal hemorrhage resulting from portal hypertension.
Prothrombin time was identi- fied as a better marker of hepatocellular function than albumin because prothrombin more accurately estimates biosynthetic function of the liver.
More recently, the Model for End-Stage Liver Disease score has been used to guide patient selection and prog- nosticate morbidity and mortality in patients with chronic liver disease undergoing major operations. fte score is determined through calculations incorporating serum bilirubin, prothrombin time/international normalized ratio, and creatinine and has been predictive in several studies looking at outcomes. fte Model for End-Stage Liver Disease has largely supplanted older subjective predictive models of outcomes such as Child-Pugh.
thromboplastin time, and the extrinsic pathway, initiated by tissue injury and release of tissue factor, is measured by the prothrombin time.
Prothrombin time and partial thromboplastin time are not functional tests of clotting and are limited in assessing clot strength, durability, or the quality of the clot formed by the inter- play of platelets, von Willebrand factor, and fibrin.،Prolongation of prothrombin time (PT) or
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